So there is great facility of system configuration which will use for windows to boot in safe mode till then you turn off the option.
Force Windows to Boot into Safe Mode
Open the Search box from the Start menu and write there msconfig and press Enter.
The window of system configuration will open, chose the Boot tab and then check the “Safe Boot” and on the radio button of “Minimal”.
When you will click on Ok button then the window will appear with the message of Restart the system now or later. Now the next boot will be for safe mode.
You will in safe mode when you will restart the system because it will open the safe mode page from help file in windows 7 or vista.
Now you can work here easily without that spyware
Turn Safe Mode Back Off
When you will done your work that you want here then just off the safe mode and go back to normal mode. Now for that just open system configuration window with msconfig and uncheck the “ Safe boot ” box.
This is very great method for repeatedly boot in Safe mode .